LOSARTAN POTASSIUM

PRODUCT IDENTIFICATION
CAS NO. 124750-99-8, 114798-26-4 (Parent)

LOSARTAN POTASSIUM

EINECS NO.  
FORMULA C22H22ClKN6O
MOL WT. 461.00

H.S. CODE

  

TOXICITY

  
SYNONYMS Hyzaar; Cozaar;
2-Butyl-4-chloro-1-(2'-(tetrazol-5-yl)biphenyl-4-ylmethyl)-1H-imidazole-5-methanol potassium; 2-Butyl-4-chloro-1-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)imidazole-5-methanol monopotassium salt; Cozaar; Losartan potassium; Lotim; Niten; Ocsaar; Tenopres; Potassium (2-butyl-5-chloro-3-((4-(2- L,(2,3,4-triaza-1-azanidacyclopenta-2,4- dien-5-yl)phenyl)phenyl) methyl)imidazol-4-yl) methanol
DERIVATION  

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE white to off-white crystalline powder
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER

freely soluble

pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Losartan works by preventing the action of a hormone called angiotensin II. Angiotensin II causes blood vessels to narrow, and leads to production of another hormone called aldosterone (which increases the amount of fluid in the blood). The action of losartan results in widening of blood vessels and reduction of fluid in the blood, and therefore brings about a reduction in blood pressure. (source: http://www.patient.co.uk/)

Losartan is used to treat high blood pressure (hypertension) and to reduce the risk of a stroke. It may be used alone or in combination with other agents. Losartan is in a class of drugs called angiotensin II receptor antagonists. These type of medications work by preventing the constriction (narrowing) of blood vessels (veins and arteries). Losartan was the first angiotensin II receptor antagonist to be marketed. It is currently marketed by Merck & Co. under the brand name Cozaar®. (source: http://www.losartan.com/)

Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-(p -(o-1H -tetrazol-5-ylphenyl)benzyl)imidazole-5-methanol monopotassium salt. Losartan potassium is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan. (source: http://dailymed.nlm.nih.gov/)

Angiotensin II receptor antagonists

Product

CAS RN.

1-Sarcosine-8-isoleucine angiotensin II

9088-01-1
Abitesartan 137882-98-5
Azilsartan kamedoxomil 863031-24-7
Azilsartan medoxomil 863031-21-4
Azilsartan 147403-03-0
Candesartan cilexetil 145040-37-5
Candesartan 139481-59-7
Elisartan 149968-26-3
Elisartan 158682-68-9
Embusartan 156001-18-2
Eprosartan mesylate 144143-96-4
Eprosartan 133040-01-4
Fimasartan 247257-48-3
Forasartan 145216-43-9
Irbesartan 138402-11-6
Losartan potassium 124750-99-8
Losartan 114798-26-4
Milfasartan 148564-47-0
Olmesartan medoxomil 144689-63-4
Olmesartan 144689-24-7
Pomisartan 144702-17-0
Pratosartan 153804-05-8
Ripisartan 148504-51-2
Saprisartan potassium 146613-90-3
Saprisartan 146623-69-0
Tasosartan 145733-36-4
Telmisartan 144701-48-4
Valsartan 137862-53-4
Zolasartan 145781-32-4

SALES SPECIFICATION

APPEARANCE

 white to off-white crystalline powder

ASSAY

 98.0 - 102.0%

WATER

0.5% max

pH

7.0 - 8.5

HEAVY METALS

20ppm max

RELATED SUBSTANCES

Individual impurity: 0.2% max
Total impurity: 1.0% max
TRANSPORTATION
PACKING

 

HAZARD CLASS  
UN NO.  
PRICE INFORMATION

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